Sensitive discovery of low abundance small-scale mutations
The OnTarget™ system depletes biological samples of predominant wild-type alleles, improving detection sensitivity of very low abundance somatic mutations. Unlike conventional target or mutation enrichment methods, even unknown sequence mutants are also enriched over background and wild-type DNA by at least two orders of magnitude.
For applications where the majority of DNA does not originate from the tumor, including heterogeneous tissues and blood plasma, this enrichment independent of prior sequence knowledge will improve the ability to profile and monitor tumors during treatment. Ultimately, genetic analysis of these previously unknown mutations enable researchers to:
- Identify variants linked to tumor status and drug resistance
- Detect point mutations in tumor suppressor genes
- Develop new targeted treatments and companion diagnostics
Learn more about the OnTarget™ allele enrichment technology
