Join the revolution in cancer research

Detect and monitor tumor mutations in plasma
with Boreal’s OnTarget™ platform

 


 

What is OnTarget?

Boreal’s OnTarget™ is a highly sensitive mutation detection platform that enables accurate tumor profiling and real-time monitoring of tumor evolution from cell-free DNA in plasma.

The OnTarget™ assay reveals tumor mutations that are undetectable with other methods to help guide selection of therapy, improve clinical trial efficiency, and accelerate drug development programs.

 


 

How OnTarget Works

OnTarget™ mutation detection is based on targeted analysis of mutant alleles over wild-type DNA in an optimized sample-to-answer workflow that provides single molecule sensitivity.

 

 Quantify

DNA extracted and quantified with qPCR

 Barcode

Limited-cycle PCR with sample-ID barcodes

 Select Mutations

Mutant alleles enriched over wild-type with the OnTarget™ instrument

 Construct Library

Secondary indexing barcodes added and samples pooled

 Sequence

Mutations sequenced using the MiSeq

 Analyze

Mutations quantified with the OnTarget™ data analysis software

 


 

The OnTarget Assay

OnTarget™ mutation detection is available in two convenient formats:

 

 

 


 

How to Order OnTarget

Services

Complete our sample submission form for research-use OnTarget™ mutation detection services.

System

Contact our OnTarget™ sales team to discuss optimal system configuration including instrument, reagent kits, and data analysis software.

Panels

Boreal offers pre-configured or customizable mutation panels - contact our applications team to discuss custom OnTarget™ panel development.